If you’ve been told you might start infliximab, you probably have questions. Infliximab is a biologic drug that blocks tumor necrosis factor alpha (TNF‑alpha), a key protein that drives inflammation. Doctors use it for conditions like Crohn’s disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, and some types of psoriasis.
It’s given as an intravenous (IV) infusion in a clinic or infusion center — not a pill. Typical schedules start with doses at 0, 2, and 6 weeks (induction) and then every 6–8 weeks for maintenance. Your doctor tailors the dose and spacing to your illness and response.
Before you start, you’ll need screening tests. Expect a TB test or chest X‑ray, blood tests for liver function and blood counts, and checks for hepatitis B. Why? Because infliximab suppresses part of your immune system and can let hidden infections flare up.
During infusions you might feel fine, but infusion reactions can happen. Mild reactions include flushing, headache, or fever. More serious reactions—like breathing trouble or chest tightness—are rare but require immediate care. Infusion centers monitor you and can stop treatment if needed.
The most common issues are infections (sinus, urinary, bronchitis), injection or infusion site problems, and sometimes headaches or stomach upset. Because infliximab lowers immune defenses, avoid live vaccines while you’re on it and tell your doctor right away if you have fever, persistent cough, or wounds that won’t heal.
Keep these practical tips in mind: always get baseline screening tests; carry a treatment card or note that you’re on a TNF inhibitor; don’t stop the drug suddenly without talking to your specialist; and schedule regular blood tests as advised. If you plan pregnancy, check with your specialist—there are timing and safety considerations, especially around delivery.
Biosimilars are common now. They’re not identical copies but are highly similar in safety and effect. Many health systems favor biosimilars to cut costs, and switching is often safe when supervised by your doctor.
Cost and access vary: infusions are often done in hospitals or clinics and may be covered by insurance or patient-assistance programs. If affordability is a concern, ask your clinic’s social worker or pharmacist about support options.
Final practical note: communicate. If symptoms change, if you catch an infection, or if you have concerns about side effects, tell your specialist promptly. With the right monitoring and a good care team, infliximab can be a powerful tool to control inflammation and improve quality of life.
