Think PDE5 inhibitors are just one pill for erectile dysfunction? They do more than that. Drugs like sildenafil, tadalafil, vardenafil and avanafil relax blood vessels by blocking the enzyme phosphodiesterase type 5 (PDE5). That increases blood flow where it’s needed and helps erections, and in some cases helps lungs in pulmonary hypertension.
If you are considering these drugs, you should know the basics — how fast they act, how long they last, and what can go wrong. Sildenafil and vardenafil usually start working in 30–60 minutes and last around 4–6 hours. Tadalafil can take 30–120 minutes but lasts up to 36 hours. Avanafil acts fast, sometimes within 15–30 minutes, and lasts about 6–12 hours. These differences matter when planning sex or daily dosing.
Most people think of erectile dysfunction first. That’s the main use. Tadalafil also has a daily low-dose option for men who want spontaneous activity. Doctors also prescribe PDE5 inhibitors for pulmonary arterial hypertension under different brand names and doses. Doses vary: start low if you’re older or have other health issues, and let a doctor adjust them. Never mix doses on your own.
Do not take PDE5 inhibitors with nitrates (like nitroglycerin). The combo can cause dangerous drops in blood pressure. Tell your doctor about alpha-blockers, certain blood pressure meds, and grapefruit products. Common side effects are headache, flushing, nasal congestion, and upset stomach. Rare but serious problems include sudden vision or hearing loss and priapism — painful erections lasting more than four hours. If that happens, get emergency care.
Thinking about buying PDE5 inhibitors online? Be cautious. Use licensed pharmacies, require a prescription, and check for secure payment and clear contact details. Cheap pills from unknown sellers may be counterfeit, contain the wrong dose, or harmful additives. Look for pharmacy certifications, customer reviews, and a pharmacist contact option. If a site offers huge discounts without a prescription, skip it.
Which medicine fits you depends on timing, side effects, and cost. If you need flexibility, tadalafil’s long window helps. If you want something quick, avanafil might suit you. Some people prefer sildenafil because generic versions are widely available and cheaper. Discuss with your doctor which trade-offs matter for your lifestyle.
Mild side effects often fade after a few doses. Over-the-counter pain relievers help headaches, and staying hydrated reduces flushing. If side effects persist, switch drugs or adjust dose with medical advice. Remember, these drugs enhance blood flow but don’t increase desire or fix relationship issues. If erections don’t improve, talk to a healthcare provider — tests may reveal underlying causes like low testosterone or vascular problems.
Store meds in a cool, dry place and check expiry dates. Keep a log of dose, timing, and any side effects for your doctor. If you plan travel, verify customs rules for carrying prescription medicines. Always carry a copy of the prescription when abroad.
Ask a healthcare professional.
