CPAP Dry Mouth: Causes, Fixes, and Medications That Make It Worse

When you use a CPAP machine, a device that delivers pressurized air to keep airways open during sleep for people with sleep apnea. Also known as continuous positive airway pressure therapy, it’s one of the most effective treatments for sleep apnea—but many users struggle with a side effect that ruins sleep: dry mouth. It’s not just uncomfortable. Waking up with a parched throat, cracked lips, or a sticky tongue can make you hate your CPAP, even if it’s saving your life.

Why does this happen? The air from your CPAP machine is dry, especially if you breathe through your mouth at night. But it’s not just the machine. Many common medications make dry mouth worse. Anticholinergics, a class of drugs that block acetylcholine, a nerve signal that tells your body to produce saliva. Also known as saliva-suppressing meds, they’re found in things like Benadryl, oxybutynin for overactive bladder, and even some antidepressants. If you’re taking one of these, your dry mouth isn’t just from the CPAP—it’s being doubled down by your pills. Even over-the-counter sleep aids or allergy meds can be culprits. And if you’re on multiple meds? The effect stacks up.

Fixing CPAP dry mouth isn’t about buying a new machine. It’s about smart adjustments. First, check your mask seal—if air is leaking out of your mouth, you’re losing moisture. A chin strap can help keep your mouth closed. Second, use a heated humidifier with your CPAP. It adds warmth and moisture to the air, and most people notice a difference within days. Third, drink water before bed—but avoid caffeine and alcohol. They dehydrate you and make dry mouth worse. And if you’re on anticholinergics? Talk to your doctor. There might be a safer alternative that doesn’t steal your saliva.

Some people swear by oral gels or sprays made for dry mouth, but those are temporary fixes. The real solution is addressing the root cause: air leakage, dry air, or medication side effects. And if your dry mouth is so bad it’s making you skip CPAP nights, you’re putting your health at risk. Sleep apnea doesn’t take a break—and neither should your treatment.

Below, you’ll find real-world advice from people who’ve been there. From how to spot which meds are hurting you, to simple hacks that keep your mouth moist all night, these posts give you the tools to take back your sleep—without giving up your CPAP.